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Description

DCFH-DA was diluted 1:1000 in serum-free culture medium to a final concentration of 10 mol/L

In human volunteers and patients, one major blood metabolite of isotretinoin is 4-oxo-isotretinoin which undergoes slower elimination than isotretinoin and may itself be a participant in teratogenesis

0.025-0.05% prescription tretinoin and 0.5-1% OTC retinol produce broadly comparable photoaging outcomes in head-to-head trials, though tretinoin acts faster